JentooBiology

AP® Biology · Unit 1 · Topic 1.5

Lipids

Lipids are fats, oils, and phospholipids built mostly from carbon and hydrogen; how tightly their fatty acid tails pack together determines whether they're solid or liquid, and how they orient themselves builds the cell membrane.

Fatty acids are long hydrocarbon tails attached to a carboxyl group. If every carbon in the tail is bonded to as many hydrogens as possible, the fatty acid is saturated: the tail is straight, like a straight stick. These straight tails line up against each other closely, the same way straight sticks stack neatly in a box. Close packing means strong attractions between neighboring molecules, so saturated fats like butter stay solid at room temperature. An unsaturated fatty acid has at least one carbon-carbon double bond, and in the cis form that double bond forces a permanent bend in the tail. Bent tails can't stack neatly, so the molecules stay loosely packed with weaker attractions between them, which is why oils like olive oil stay liquid.

A triglyceride is one glycerol molecule joined to three fatty acid tails by ester bonds, built the same way proteins and starch are built, by removing water to form covalent bonds. But it stops there: three tails, one glycerol, done. It never becomes a long repeating chain, so it doesn't count as a true polymer even though the bond-forming chemistry matches.

Phospholipids rearrange this same toolkit for a different job. Swap one fatty acid tail for a phosphate group and the molecule becomes two-faced: the phosphate head is polar and hydrophilic, the two remaining tails stay nonpolar and hydrophobic. Dropped in water, phospholipids spontaneously turn their heads outward and tails inward, forming the bilayer that is the cell membrane. More unsaturated kinks among those tails mean looser packing, so the membrane stays more fluid and flexible even at lower temperatures, which is exactly the saturated-versus-unsaturated logic from fats applied to membranes.

Key terms

Saturated fatty acid
A fatty acid tail with no carbon-carbon double bonds, allowing it to pack tightly with neighboring tails.
Unsaturated fatty acid
A fatty acid tail with one or more cis carbon-carbon double bonds that create a permanent kink.
Triglyceride
A lipid made of one glycerol molecule bonded to three fatty acid tails by ester bonds.
Phospholipid
A lipid with a hydrophilic phosphate head and two hydrophobic fatty acid tails, forming the cell membrane bilayer.
Polymer
A large molecule made of many repeating monomer units joined in a long chain.

Watch it explained

  1. How it worksHow does one carbon double bond put a permanent kink in a fatty acid tail?
  2. How it worksWalk me through how kinked tails stop fat molecules from packing tightly together.
  3. How it worksHow does a phospholipid manage to be water loving at one end and water hating at the other?
  4. Common mistakeWhy isn't a lipid a polymer the way starch and protein are?
  5. Going furtherWhat happens to a membrane's stiffness when its lipids get more unsaturated?

Check yourself

Your turn1 of 2
Olive oil (mostly unsaturated fat) is liquid at room temperature, while butter (mostly saturated fat) is solid. What actually causes this difference?

End of topic.